Hotel Cactus was among the first hotels built and operated by hotel magnate Conrad Hilton. For many years the lobby of the Cactus was the meeting and informal business headquarters for ranchers, livestock dealers and other "wheeler dealers" of the prosperous agriculture center of San Angelo, Texas.
With 14 stories the hotel is the tallest building in downtown San Angelo. The hotel no longer operates as an inn, but rather rents out apartments and offices.